KOALA from ImageBiopsy Lab

KOALA (Knee OA Labeling Assistant) is a radiological fully-automated image processing software device intended to aid medical professionals in the measurement of standard joint space width parameters, as well as perform an assessment of OARSI grades for sclerosis, joint space narrowing and osteophytes, and an OA classification of the joint according to Kellgren & Lawrence of standing, fixed-flexion radiographs of the knee.

It should not be used in lieu of full patient evaluation or solely relied upon to make or confirm a diagnosis. The system is to be used by trained professionals including, but not limited to, radiologists, orthopedics, physicians and medical technicians.

Product Features:

• Inter-rater variability has been a challenge for OA severity classification such as KL and OARSI grades
• A reader study shows that physicians reading radiographs for KL and OARSI grades show significantly improved agreement rates when aided by KOALA’s report. Improvements in agreement rates range from 37% for Joint Space Narrowing OARSI grades to 101% for KL grades

• A reader study shows that the physicians’ rate of false positives for KL and OARSI grades decreases greatly when compared to the gold standard: False positive rates decrease by 29% for the detection of any knee joint abnormality, 43% for the detection of osteophytes,  and by 66% for the detection of severe sclerosis.

• KOALA provides a standardized report that can be produced automatically as the radiographs enter the PACS system. This supports the physician’s workflow by saving time and ensures an auditable record of the patient’s exams

Clinically Relevant OA Inclusion/Exclusion Criteria

• KOALA provides indicators for presence/absence of the relevant OA features: Joint space narrowing, Osteophyptes and Sclerosis, supportive for the stratification of cohorts for clinical studies.